STEAP1 Gene Summary [Human]
This gene is predominantly expressed in prostate tissue, and is found to be upregulated in multiple cancer cell lines. The gene product is predicted to be a six-transmembrane protein, and was shown to be a cell surface antigen significantly expressed at cell-cell junctions. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | STEAP1 |
| Official Name | STEAP family member 1 [Source:HGNC Symbol;Acc:HGNC:11378] |
| Ensembl ID | ENSG00000164647 |
| Bio databases IDs | |
| Aliases | STEAP family member 1 |
| Synonyms | 2410007B19Rik, PRSS24, six transmembrane epithelial antigen of the prostate 1, STEAP, STEAP family member 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human STEAP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cytochrome_b_N
- enzyme
- protein binding
- heme binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
role in cell
- expression in
- induction
- number
- phosphorylation in
- differentiation
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cellular membrane
- endosomes
- intercellular junctions
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human STEAP1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- endosome
- membrane
- endosome membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ferric-chelate reductase (NADPH) activity
- metal ion binding
- heme binding