PRKACG Gene Summary [Human]
Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PRKACG |
| Official Name | protein kinase cAMP-activated catalytic subunit gamma [Source:HGNC Symbol;Acc:HGNC:9382] |
| Ensembl ID | ENSG00000165059 |
| Bio databases IDs | |
| Aliases | protein kinase cAMP-activated catalytic subunit gamma |
| Synonyms | BDPLT19, KAPG, PKACg, PKA C gamma, PKA C γ, protein kinase cAMP-activated catalytic subunit gamma, protein kinase cAMP-activated catalytic subunit γ |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRKACG often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- cAMP-dependent protein kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- Kinase-like
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the PRKACG gene in human plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Apelin Adipocyte Signaling Pathway
- Apelin Pancreas Signaling Pathway
- BMP signaling pathway
- Calcium Signaling
- CDK5 Signaling
- Corticotropin Releasing Hormone Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Endocannabinoid Developing Neuron Pathway
- eNOS Signaling
- Ephrin A Signaling
- Glucocorticoid Receptor Signaling
- Gαi Signaling
- IL-1 Signaling
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- Myc Mediated Apoptosis Signaling
- Netrin Signaling
- Neuropathic Pain Signaling In Dorsal Horn Neurons
- NF-κB Signaling
- P2Y Purinergic Receptor Signaling Pathway
- Phototransduction Pathway
- PXR/RXR Activation
- Sonic Hedgehog Signaling
- Tight Junction Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRKACG gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- renal water homeostasis
- high-density lipoprotein particle assembly
- male gonad development
- spermatogenesis
- protein kinase A signaling cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- cAMP-dependent protein kinase complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- AMP-activated protein kinase activity
- protein binding
- protein kinase A regulatory subunit binding
- cAMP-dependent protein kinase activity
- protein serine/threonine kinase activity