CLMN Gene Summary [Human]
Predicted to enable actin filament binding activity. Predicted to be involved in negative regulation of cell population proliferation and nuclear migration. Predicted to act upstream of or within neuron projection development. Predicted to be integral component of membrane. Predicted to be part of meiotic nuclear membrane microtubule tethering complex. Predicted to be active in cytoplasm and nuclear outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | CLMN |
| Official Name | calmin [Source:HGNC Symbol;Acc:HGNC:19972] |
| Ensembl ID | ENSG00000165959 |
| Bio databases IDs | |
| Aliases | calmin |
| Synonyms | 9330188N17RIK, AI788815, Calmin, KIAA0500, mKIAA1188 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CLMN often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calponin homology domain
- calponin homology (CH) domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CLMN gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuron projection development
- negative regulation of cell proliferation
- nuclear migration
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- nuclear outer membrane
- SUN-KASH complex
Molecular Function
What the gene product does at the molecular level
- actin filament binding