PLD4 Gene Summary [Human]
Predicted to enable single-stranded DNA 5'-3' exodeoxyribonuclease activity. Predicted to be involved in hematopoietic progenitor cell differentiation; phagocytosis; and regulation of cytokine production involved in inflammatory response. Predicted to be located in early endosome and endoplasmic reticulum membrane. Predicted to be active in several cellular components, including endoplasmic reticulum; phagocytic vesicle; and trans-Golgi network membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PLD4 |
| Official Name | phospholipase D family member 4 [Source:HGNC Symbol;Acc:HGNC:23792] |
| Ensembl ID | ENSG00000166428 |
| Bio databases IDs | |
| Aliases | phospholipase D family member 4 |
| Synonyms | AC124353.2, AI132321, C14orf175, LOC122618, phospholipase D family member 4, phospholipase D family, member 4, thss |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PLD4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phospholipase D Active site motif
- phospholipase D
- PLD-like domain
- enzyme
- protein binding
- Catalytic domain of phospholipase D superfamily proteins
- single-stranded DNA specific 5'-3' exodeoxyribonuclease
Pathways
Biological processes and signaling networks where the PLD4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- rheumatoid arthritis
- insulin-dependent diabetes mellitus
- thrombocytopenia
role in cell
- expression in
- number
- differentiation
- quantity
- phagocytosis by
- autophagy in
- autophagy
- abnormal quantity
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- trans Golgi network
- early endosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PLD4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- innate immune response
- phagocytosis
- regulation of cytokine production involved in inflammatory response
- establishment of localization in cell
- DNA metabolic process
- hemopoietic progenitor cell differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- early endosome
- phagocytic vesicle
- endoplasmic reticulum
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- single-stranded DNA specific 5'-3' exodeoxyribonuclease activity
- phospholipase D activity