Pld4 Gene Summary [Mouse]
Enables single-stranded DNA 5'-3' DNA exonuclease activity. Involved in regulation of cytokine production involved in inflammatory response. Acts upstream of or within establishment of localization in cell; hematopoietic progenitor cell differentiation; and phagocytosis. Located in several cellular components, including cytoplasmic vesicle; endoplasmic reticulum membrane; and trans-Golgi network membrane. Is expressed in brain and hemolymphoid system. Used to study systemic lupus erythematosus. Orthologous to human PLD4 (phospholipase D family member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pld4 |
| Official Name | phospholipase D family, member 4 [Source:MGI Symbol;Acc:MGI:2144765] |
| Ensembl ID | ENSMUSG00000052160 |
| Bio databases IDs | |
| Aliases | phospholipase D family, member 4 |
| Synonyms | AC124353.2, AI132321, C14orf175, LOC122618, phospholipase D family member 4, phospholipase D family, member 4, thss |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pld4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Phospholipase D Active site motif
- phospholipase D
- PLD-like domain
- enzyme
- protein binding
- Catalytic domain of phospholipase D superfamily proteins
- single-stranded DNA specific 5'-3' exodeoxyribonuclease
Pathways
Biological processes and signaling networks where the Pld4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- rheumatoid arthritis
- insulin-dependent diabetes mellitus
- thrombocytopenia
role in cell
- expression in
- number
- differentiation
- quantity
- phagocytosis by
- autophagy in
- autophagy
- abnormal quantity
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Nucleus
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- trans Golgi network
- early endosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pld4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- innate immune response
- phagocytosis
- regulation of cytokine production involved in inflammatory response
- establishment of localization in cell
- DNA metabolic process
- hemopoietic progenitor cell differentiation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nucleus
- early endosome
- phagocytic vesicle
- endoplasmic reticulum
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- single-stranded DNA specific 5'-3' exodeoxyribonuclease activity
- phospholipase D activity