LEO1 Gene Summary [Human]
LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | LEO1 |
| Official Name | LEO1 homolog, Paf1/RNA polymerase II complex component [Source:HGNC Symbol;Acc:HGNC:30401] |
| Ensembl ID | ENSG00000166477 |
| Bio databases IDs | |
| Aliases | LEO1 homolog, Paf1/RNA polymerase II complex component |
| Synonyms | Gm185, LEO1 homolog, Paf1/RNA polymerase II complex component, Leo1, Paf1/RNA polymerase II complex component, RDL |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LEO1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Leo1-like protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- systemic sclerosis
- osteoarthritis
role in cell
- differentiation
- expression in
- growth
- survival
- colony formation
- transactivation in
- maintenance
- UVC radiation sensitivity
- cisplatin sensitivity
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- centrosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LEO1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- negative regulation of myeloid cell differentiation
- stem cell maintenance
- endodermal cell fate commitment
- mRNA 3'-end processing
- Wnt receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- Cdc73/Paf1 complex
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding