Leo1 Gene Summary [Mouse]
Predicted to enable RNA polymerase II C-terminal domain phosphoserine binding activity. Involved in endodermal cell fate commitment and stem cell population maintenance. Predicted to be located in centrosome; fibrillar center; and nucleoplasm. Predicted to be part of Cdc73/Paf1 complex. Predicted to be active in nucleus. Is expressed in brain; gonad; heart; and medial-nasal process mesenchyme. Orthologous to human LEO1 (LEO1 homolog, Paf1/RNA polymerase II complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Leo1 |
| Official Name | Leo1, Paf1/RNA polymerase II complex component [Source:MGI Symbol;Acc:MGI:2685031] |
| Ensembl ID | ENSMUSG00000042487 |
| Bio databases IDs | |
| Aliases | Leo1, Paf1/RNA polymerase II complex component |
| Synonyms | Gm185, LEO1 homolog, Paf1/RNA polymerase II complex component, Leo1, Paf1/RNA polymerase II complex component, RDL |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Leo1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Leo1-like protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lung cancer
- systemic sclerosis
- osteoarthritis
role in cell
- differentiation
- expression in
- growth
- survival
- colony formation
- transactivation in
- maintenance
- UVC radiation sensitivity
- cisplatin sensitivity
- recruitment in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- centrosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Leo1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- negative regulation of myeloid cell differentiation
- stem cell maintenance
- endodermal cell fate commitment
- mRNA 3'-end processing
- Wnt receptor signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- Cdc73/Paf1 complex
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding