JSRP1 Gene Summary [Human]
The protein encoded by this gene is involved in excitation-contraction coupling at the sarcoplasmic reticulum. The encoded protein can interact with CACNA1S, CACNB1, and calsequestrin to help regulate calcium influx and efflux in skeletal muscle. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | JSRP1 |
| Official Name | junctional sarcoplasmic reticulum protein 1 [Source:HGNC Symbol;Acc:HGNC:24963] |
| Ensembl ID | ENSG00000167476 |
| Bio databases IDs | |
| Aliases | junctional sarcoplasmic reticulum protein 1, homolog of mouse skeletal muscle sarcoplasmic reticulum protein JP-45 |
| Synonyms | 2300003C06Rik, 2310032K21Rik, JP-45, junctional sarcoplasmic reticulum protein 1, LOC686460 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human JSRP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Junctional sarcoplasmic reticulum protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- intracellular membranes
- sarcoplasmic reticulum
- triad junctions
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human JSRP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal muscle contraction
- regulation of ryanodine-sensitive calcium-release channel activity
Cellular Component
Where in the cell the gene product is active
- sarcoplasmic reticulum
- sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding