Zfp598 Gene Summary [Mouse]
Predicted to enable several functions, including ribosome binding activity; stalled ribosome sensor activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including protein ubiquitination; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in cytosolic ribosome. Is expressed in early conceptus; future spinal cord; inner cell mass; and oocyte. Orthologous to human ZNF598 (zinc finger protein 598, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp598 |
| Official Name | zinc finger protein 598 [Source:MGI Symbol;Acc:MGI:2670965] |
| Ensembl ID | ENSMUSG00000041130 |
| Bio databases IDs | |
| Aliases | zinc finger protein 598 |
| Synonyms | HEL2, Ntrap, Zfp598, zinc finger protein 598, zinc finger protein 598, E3 ubiquitin ligase |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp598 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- protein binding activity, bridging
- ribosome binding
- enzyme
- protein binding
- enzyme regulator activity
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- ribosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp598 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of translational initiation
- rescue of stalled ribosome
- protein K63-linked ubiquitination
- protein monoubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytosolic ribosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- metal ion binding
- ribosome binding