PBK Gene Summary [Human]
This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | PBK |
| Official Name | PDZ binding kinase [Source:HGNC Symbol;Acc:HGNC:18282] |
| Ensembl ID | ENSG00000168078 |
| Bio databases IDs | |
| Aliases | PDZ binding kinase, T-LAK cell-originated protein kinase, cancer/testis antigen 84 |
| Synonyms | 2810434B10Rik, 3A11 Ag, CT84, D14Ertd732e, HEL164, Nori-3, PDZ binding kinase, SPERMATOGENESIS RELATED protein KINASE, SPK, TOPK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PBK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-small cell lung cancer
- liver cancer
- cancer
- epithelial neoplasia
- fibrosis
- lung adenocarcinoma
- lung adenocarcinoma formation
- colon cancer
- hepatocellular carcinoma
role in cell
- phosphorylation in
- cell death
- expression in
- proliferation
- apoptosis
- migration
- survival
- transformation
- growth
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PBK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of protein phosphorylation
- negative regulation of inflammatory response
- cellular response to UV
- negative regulation of stress-activated MAPK cascade
- peptidyl-serine phosphorylation
- mitotic cell cycle
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
- stress-activated MAPK cascade
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- protein binding
- MAP kinase kinase activity
- protein serine/threonine kinase activity