Ptgdr Gene Summary [Mouse]
Enables prostaglandin D receptor activity and prostaglandin J receptor activity. Acts upstream of or within several processes, including adenosine metabolic process; cellular response to prostaglandin D stimulus; and male sex determination. Located in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and respiratory system. Human ortholog(s) of this gene implicated in asthma. Orthologous to human PTGDR (prostaglandin D2 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptgdr |
| Official Name | prostaglandin D receptor [Source:MGI Symbol;Acc:MGI:102966] |
| Ensembl ID | ENSMUSG00000071489 |
| Bio databases IDs | |
| Aliases | prostaglandin D receptor |
| Synonyms | AS1, ASRT1, DP, DP1, Dp1r, Dp2, DP-R, LOC100365135, PGD, PGD2 receptor, prostaglandin D2 receptor, prostaglandin D receptor, PTGDR1, Ptgdr2, Ptgdrl |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptgdr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- prostaglandin receptor
- extracellular domain
- prostaglandin D receptor
- transmembrane domain
- extracellular loop
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Ptgdr gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- dyslipidemia
- cardiovascular disorder
- hypercholesterolemia
- hypersensitivity reaction type I
- mixed dyslipidemia
- mixed hyperlipidemia
- vasomotor rhinitis
- primary hypercholesterolemia
- hyperlipidemia
role in cell
- activation in
- chemotaxis
- migration
- expression in
- transendothelial migration
- activation
- function
- phosphorylation in
- number
- M2 polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- cellular membrane
- vesicles
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptgdr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male sex determination
- inflammatory response
- adenosine metabolic process
- G-protein coupled receptor signaling pathway
- cellular response to prostaglandin D stimulus
- sleep
- mast cell degranulation
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- prostaglandin J receptor activity
- protein binding
- prostaglandin D receptor activity