Ptpn9 Gene Summary [Mouse]
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within negative regulation of neuron projection development; peptidyl-tyrosine dephosphorylation; and positive regulation of protein localization to plasma membrane. Located in neuron projection terminus. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human PTPN9 (protein tyrosine phosphatase non-receptor type 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptpn9 |
| Official Name | protein tyrosine phosphatase, non-receptor type 9 [Source:MGI Symbol;Acc:MGI:1928376] |
| Ensembl ID | ENSMUSG00000032290 |
| Bio databases IDs | |
| Aliases | protein tyrosine phosphatase, non-receptor type 9 |
| Synonyms | MEG2, protein tyrosine phosphatase non-receptor type 9, protein tyrosine phosphatase, non-receptor type 9, PTPMEG2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ptpn9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in homologues of a S
- non-membrane spanning protein tyrosine phosphatase
- protein-tyrosine-phoshatase
- Protein tyrosine phosphatase, catalytic domain
- protein binding
- PTP_DSP_cys
- Protein tyrosine phosphatase, catalytic domain motif
- Protein tyrosine phosphatase, catalytic domain, undefined specificity
- Protein-tyrosine phosphatase
- CRAL/TRIO, N-terminal domain
- Divergent CRAL/TRIO domain
- phosphatase
- CRAL/TRIO domain
- Sec14 domain
Pathways
Biological processes and signaling networks where the Ptpn9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- growth failure
- breast carcinoma
- pancreatic epithelial cancer
- tremor
- meningomyelocele
- bleeding
- exencephaly
- encephalocele
- diabetes mellitus
role in cell
- expression in
- growth
- activation in
- proliferation
- survival
- differentiation
- degranulation
- diameter
- aggregation
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- perinuclear region
- granules
- nucleoplasm
- nerve ending
- secretory vesicles
- specific granules
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ptpn9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of neuron projection development
- protein dephosphorylation
- peptidyl-tyrosine dephosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- neuron projection terminus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- non-membrane spanning protein tyrosine phosphatase activity
- protein tyrosine phosphatase activity