USP38 Gene Summary [Human]
Enables thiol-dependent deubiquitinase. Involved in protein deubiquitination. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | USP38 |
| Official Name | ubiquitin specific peptidase 38 [Source:HGNC Symbol;Acc:HGNC:20067] |
| Ensembl ID | ENSG00000170185 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 38 |
| Synonyms | 4631402N15Rik, 4833420O05RIK, HP43.8KD, mKIAA1891, ubiquitin specific peptidase 38 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human USP38 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- ubiquitin-specific protease
- Ubiquitin carboxyl-terminal hydrolase
- protein binding
- Peptidase_C19
Pathways
Biological processes and signaling networks where the USP38 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal clear cell adenocarcinoma
- renal clear cell cancer
- renal failure
- pulmonary fibrosis
role in cell
- expression in
- number
- differentiation
- migration
- phosphorylation in
- accumulation in
- activation in
- apoptosis
- production in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human USP38 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- negative regulation of innate immune response
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding