AHSG
AHSG Gene Summary
The protein encoded by this gene is a negatively-charged serum glycoprotein that is synthesized by hepatocytes. The encoded protein consists of two polypeptide chains, which are both cleaved from a proprotein encoded from a single mRNA. It is involved in several processes, including endocytosis, brain development, and the formation of bone tissue. Defects in this gene are a cause of susceptibility to leanness. [provided by RefSeq, Aug 2017]
Details
| Type | Protein Coding |
| Official Symbol | AHSG |
| Official Name | alpha 2-HS glycoprotein [Source:HGNC Symbol;Acc:HGNC:349] |
| Ensembl ID | ENSG00000145192 |
| Bio databases IDs | |
| Aliases | alpha 2-HS glycoprotein, fetuin A |
| Synonyms | A2HS,Aa2-066,AHS,alpha2 HEREMANS SCHMID GLYCOPROTEIN,alpha2 HSG,alpha-2-HS-GLYCOPROTEIN,APMR1,BSP,FETUA,FETUIN A,HSGA,pp63,α-2-HS-GLYCOPROTEIN |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CY
- receptor signaling protein tyrosine kinase inhibitor activity
- protein binding
Pathways
Biological processes and signaling networks where the AHSG gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CA8
- SERBP1
- FBXO2
- TRIM21
- AKT1
- FBL
- GNG8
- CDC123
- HRAS
- EGFR
disease
- neoplasia
- diabetes mellitus
- metastasis
- rheumatoid arthritis
- Alzheimer disease
- vascular calcification
- liver cancer
- insulin resistance
- atherosclerosis
- age-related hearing loss
regulated by
- phosphate
- Ca2+
- AHR
- thapsigargin
- simvastatin
- 4-phenylbutyric acid
- LIF
- PDIA3
- PDI
- palmitic acid
regulates
- AKT
- TIMP1
- TNF
- IL6
- INS
- NFkB (complex)
- insulin
- CXCL8
- FN1
- SPP1
role in cell
- expression in
- migration
- activation in
- growth
- adhesion
- M1 polarization
- ossification by
- phagocytosis by
- mitogenesis in
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- detergent resistant lipid raft fraction
- secretory granule lumen
- Nucleus
- Golgi Apparatus
- Mitochondria
- cytosol
- endoplasmic reticulum lumen
- alpha granules
- extracellular matrix
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the AHSG gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- negative regulation of bone mineralization
- skeletal system development
- ossification
- regulation of inflammatory response
- negative regulation of endopeptidase activity
- pinocytosis
- positive regulation of phagocytosis
- negative regulation of insulin receptor signaling pathway
- acute-phase response
- regulation of bone mineralization
CELLULAR COMPONENT
Where in the cell the gene product is active
- platelet alpha granule lumen
- endoplasmic reticulum lumen
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- Golgi apparatus
- secretory granule lumen
- extracellular matrix
- extracellular region
MOLECULAR FUNCTION
What the gene product does at the molecular level
- endopeptidase inhibitor activity
- cysteine-type endopeptidase inhibitor activity
- kinase inhibitor activity