BICC1 Gene Summary [Human]
This gene encodes an RNA-binding protein that is active in regulating gene expression by modulating protein translation during embryonic development. Mouse studies identified the corresponding protein to be under strict control during cell differentiation and to be a maternally provided gene product. [provided by RefSeq, Apr 2009]
Details
| Type | Protein Coding |
| Official Symbol | BICC1 |
| Official Name | BicC family RNA binding protein 1 [Source:HGNC Symbol;Acc:HGNC:19351] |
| Ensembl ID | ENSG00000122870 |
| Bio databases IDs | |
| Aliases | BicC family RNA binding protein 1 |
| Synonyms | BICC, BicC family RNA binding protein 1, bpk, jcpk |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BICC1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Sterile alpha motif
- K homology (KH) RNA-binding domain, type I
- KH domain
- SAM (Sterile alpha motif )
- SAM domain
- SAM domain (Sterile alpha motif)
- protein binding
- K homology RNA-binding domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- hypertension
- schizophrenia
- susceptibility to cystic renal dysplasia
- chronic kidney disease
- coronary artery disease
- gout
- open-angle glaucoma
- refractive error
- ventricular septal defect
role in cell
- proliferation
- expression in
- cell viability
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BICC1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- heart development
- kidney development
- determination of left/right symmetry
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding