MAP4K2 Gene Summary [Human]
The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in many tissues, its expression in lymphoid follicles is restricted to the cells of germinal centre, where it may participate in B-cell differentiation. This kinase can be activated by TNF-alpha, and has been shown to specifically activate MAP kinases. This kinase is also found to interact with TNF receptor-associated factor 2 (TRAF2), which is involved in the activation of MAP3K1/MEKK1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Details
| Type | Protein Coding |
| Official Symbol | MAP4K2 |
| Official Name | mitogen-activated protein kinase kinase kinase kinase 2 [Source:HGNC Symbol;Acc:HGNC:6864] |
| Ensembl ID | ENSG00000168067 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase kinase 2 |
| Synonyms | BL44, GCK, mitogen-activated protein kinase kinase kinase kinase 2, RAB8IP |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP4K2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- leucine rich domain
- Protein kinase (unclassified specificity)
- protein kinase binding
- regulatory domain
- Protein tyrosine and serine/threonine kinase
- CNH domain
- ATP binding
- protein binding
- Protein kinase domain
- Sh3 domain binding motif
- kinase
- germinal center kinase homology domain
- Serine/Threonine protein kinases, catalytic domain
- PEST domain
- kinase domain
- Protein Kinases, catalytic domain
- C-terminal extension
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the MAP4K2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- expression in
- phosphorylation in
- apoptosis
- targeting
- signal transduction in
- entrance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- cytosol
- basolateral membrane
- Golgi membrane
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP4K2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JUN kinase activity
- immune response
- positive regulation of JNK cascade
- innate immune response
- vesicle targeting
- JNK cascade
- protein phosphorylation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- Golgi membrane
- basolateral plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein serine/threonine kinase activity
- mitogen-activated protein kinase kinase kinase binding
- MAP kinase kinase kinase kinase activity