CHST11 Gene Summary [Human]
The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Details
| Type | Processed Transcript |
| Official Symbol | CHST11 |
| Official Name | carbohydrate sulfotransferase 11 [Source:HGNC Symbol;Acc:HGNC:17422] |
| Ensembl ID | ENSG00000171310 |
| Bio databases IDs | |
| Aliases | carbohydrate sulfotransferase 11, chondroitin 4-sulfotransferase 1 |
| Synonyms | 1110020P09RIK, C4s, C4ST, C4ST-1, carbohydrate sulfotransferase 11, carbohydrate sulphotransferase 11, chondroitin 4 sulphotransferase, HSA269537, OCBMD |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CHST11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
- sulfotransferase
- N-acetylgalactosamine-4-O-sulfotransferase
- enzyme
- chondroitin 4-sulfotransferase
- Sulfotransferase family
Pathways
Biological processes and signaling networks where the CHST11 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thrombocytopenia
- Alzheimer disease
- osteochondrodysplasia, brachydactyly, and overlapping malformed digits
- colorectal cancer
- cannabis dependence
role in cell
- apoptosis
- expression in
- proliferation
- phosphorylation in
- activity
- development
- G2/M phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CHST11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- post-embryonic development
- transforming growth factor beta receptor signaling pathway
- chondrocyte development
- respiratory gaseous exchange
- developmental growth
- regulation of cell proliferation
- embryonic digit morphogenesis
- embryonic viscerocranium morphogenesis
- chondroitin sulfate biosynthetic process
- in utero embryonic development
- carbohydrate biosynthetic process
- negative regulation of apoptotic process
- apoptotic process
- polysaccharide localization
- proteoglycan biosynthetic process
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- N-acetylgalactosamine 4-O-sulfotransferase activity
- chondroitin 4-sulfotransferase activity
- sulfotransferase activity
- N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity