Chst11 Gene Summary [Mouse]
Enables N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity. Acts upstream of or within several processes, including chondroitin sulfate proteoglycan biosynthetic process; post-anal tail morphogenesis; and skeletal system development. Predicted to be located in Golgi membrane. Is expressed in several structures, including alimentary system; central nervous system; ear; heart; and skeletal system. Orthologous to human CHST11 (carbohydrate sulfotransferase 11). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chst11 |
| Official Name | carbohydrate sulfotransferase 11 [Source:MGI Symbol;Acc:MGI:1927166] |
| Ensembl ID | ENSMUSG00000034612 |
| Bio databases IDs | |
| Aliases | carbohydrate sulfotransferase 11 |
| Synonyms | 1110020P09RIK, C4s, C4ST, C4ST-1, carbohydrate sulfotransferase 11, carbohydrate sulphotransferase 11, chondroitin 4 sulphotransferase, HSA269537, OCBMD |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chst11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase
- sulfotransferase
- N-acetylgalactosamine-4-O-sulfotransferase
- enzyme
- chondroitin 4-sulfotransferase
- Sulfotransferase family
Pathways
Biological processes and signaling networks where the Chst11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thrombocytopenia
- Alzheimer disease
- osteochondrodysplasia, brachydactyly, and overlapping malformed digits
- colorectal cancer
- cannabis dependence
role in cell
- apoptosis
- expression in
- proliferation
- phosphorylation in
- activity
- development
- G2/M phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chst11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- post-embryonic development
- transforming growth factor beta receptor signaling pathway
- chondrocyte development
- respiratory gaseous exchange
- developmental growth
- regulation of cell proliferation
- embryonic digit morphogenesis
- embryonic viscerocranium morphogenesis
- chondroitin sulfate biosynthetic process
- in utero embryonic development
- carbohydrate biosynthetic process
- negative regulation of apoptotic process
- apoptotic process
- polysaccharide localization
- proteoglycan biosynthetic process
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- N-acetylgalactosamine 4-O-sulfotransferase activity
- chondroitin 4-sulfotransferase activity
- sulfotransferase activity
- N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity