VAMP7 Gene Summary [Human]
This gene encodes a transmembrane protein that is a member of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) family. The encoded protein localizes to late endosomes and lysosomes and is involved in the fusion of transport vesicles to their target membranes. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]
Details
| Type | Protein Coding |
| Official Symbol | VAMP7 |
| Official Name | vesicle associated membrane protein 7 [Source:HGNC Symbol;Acc:HGNC:11486] |
| Ensembl ID | ENSG00000124333 |
| Bio databases IDs | |
| Aliases | vesicle associated membrane protein 7 |
| Synonyms | SYBL1, TI-VAMP, TI-VAMP7, vesicle-associated membrane protein 7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VAMP7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Regulated-SNARE-like domain
- SNAP receptor
- cytoplasmic domain
- transmembrane domain
- coiled-coil domain
- protein binding
- SNARE motif
- Longin-like domains
- transporter
- syntaxin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- neoplasia
- metastasis
role in cell
- aggregation
- migration
- formation
- activity
- growth
- fusion
- degranulation
- invasion
- exocytosis
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- pH resistant lipid raft fraction
- synaptic vesicle membrane
- pre-chylomicron transport vesicle
- endocytic vesicle membrane
- intracellular membrane-bounded organelle
- invadopodia
- cell surface
- cell periphery
- apical compartment
- perinuclear region
- cellular membrane
- Plasma Membrane
- endosomes
- vesicles
- lysosome
- Golgi Apparatus
- secretory granule membrane
- endoplasmic reticulum membrane
- trans Golgi network
- lysosome membrane
- endosomal membrane
- alpha granules
- synaptic vesicles
- neurites
- nerve ending
- synapse
- recycling endosomes
- late endosomes
- transport vesicles
- synaptic-like microvesicles
- azurophil granules
- secretory granules
- pseudopodia
- filopodia
- perikaryon
- clathrin-coated vesicles
- phagosomes
- lamellipodia
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VAMP7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ER to Golgi vesicle-mediated transport
- vesicle-mediated transport
- phagocytosis, engulfment
- eosinophil degranulation
- vesicle fusion
- protein transport
- natural killer cell degranulation
- endosome to lysosome transport
- calcium ion-dependent exocytosis
- neutrophil degranulation
- exocytosis
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule
- secretory granule
- phagocytic vesicle
- synapse
- neuron projection
- plasma membrane
- lysosomal membrane
- endoplasmic reticulum membrane
- late endosome membrane
- secretory granule membrane
- trans-Golgi network
- transport vesicle membrane
- clathrin-coated endocytic vesicle membrane
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- phagocytic vesicle membrane
- SNARE complex
- pseudopodium
- azurophil granule membrane
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- protein binding
- SNAP receptor activity
- SNARE binding