HOXB2 Gene Summary [Human]
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with pancreatic cancer. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | HOXB2 |
| Official Name | homeobox B2 [Source:HGNC Symbol;Acc:HGNC:5113] |
| Ensembl ID | ENSG00000173917 |
| Bio databases IDs | |
| Aliases | homeobox B2 |
| Synonyms | homeobox B2, HOX2, Hox-2.8, HOX2H, Hoxbes2, K8, LOC100365058 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HOXB2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- tankyrase binding domain
- double-stranded DNA binding
- protein binding
- sequence-specific DNA binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- pancreatic intraepithelial neoplasm
- pancreatic intraepithelial neoplasia
- pancreatic cancer
- dyspnea
- Crohn disease
role in cell
- migration
- differentiation
- number
- abnormal morphology
- transactivation in
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HOXB2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rhombomere 4 development
- nervous system development
- anterior/posterior pattern specification
- facial nerve structural organization
- rhombomere 3 development
- morphogenesis of an epithelial sheet
- positive regulation of transcription from RNA polymerase II promoter
- embryonic skeletal system morphogenesis
- dorsal/ventral pattern formation
- neural nucleus development
Cellular Component
Where in the cell the gene product is active
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity