NR1D2 Gene Summary [Human]
This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]
Details
| Type | Protein Coding |
| Official Symbol | NR1D2 |
| Official Name | nuclear receptor subfamily 1 group D member 2 [Source:HGNC Symbol;Acc:HGNC:7963] |
| Ensembl ID | ENSG00000174738 |
| Bio databases IDs | |
| Aliases | nuclear receptor subfamily 1 group D member 2 |
| Synonyms | BD73, EAR-1R, HZF-2, nuclear receptor subfamily 1 group D member 2, nuclear receptor subfamily 1, group D, member 2, Rev-erb, Rev-erba-beta, Rev-erba-β, REVERBB, REVERBbeta, Rev-Erb β, RVR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NR1D2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- nuclear receptor ligand binding domain
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- ligand-binding domain
- double-stranded DNA binding
- ligand-dependent nuclear receptor
- corepressor binding domain
- Ligand-binding domain of nuclear hormone receptor
- transcription factor activity
Pathways
Biological processes and signaling networks where the NR1D2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pervasive developmental disorder
- ischemic stroke
- Parkinson disease
- non-insulin-dependent diabetes mellitus
- psoriasis
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NR1D2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of inflammatory response
- lipid homeostasis
- regulation of transcription, DNA-dependent
- circadian behavior
- regulation of circadian rhythm
- positive regulation of transcription from RNA polymerase II promoter
- hormone-mediated signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- cell differentiation
- energy homeostasis
- regulation of inflammatory response
- regulation of lipid metabolic process
- regulation of skeletal muscle cell differentiation
- intracellular receptor mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity