RNF152 Gene Summary [Human]
Enables small GTPase binding activity and ubiquitin protein ligase activity. Involved in several processes, including cellular response to amino acid starvation; negative regulation of TORC1 signaling; and protein polyubiquitination. Located in lysosomal membrane. Is integral component of organelle membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | RNF152 |
| Official Name | ring finger protein 152 [Source:HGNC Symbol;Acc:HGNC:26811] |
| Ensembl ID | ENSG00000176641 |
| Bio databases IDs | |
| Aliases | ring finger protein 152 |
| Synonyms | A930029B02RIK, ring finger protein 152 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RNF152 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- enzyme binding
- enzyme
- Ring finger domain
- protein binding
- E3 ubiquitin-protein ligase RNF152 C-terminus
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- apoptosis
- expression in
- activation in
- phosphorylation in
- autophagy by
- response by
- oligomerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- lysosome
- lysosome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RNF152 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of autophagy
- protein K48-linked ubiquitination
- cellular response to amino acid starvation
- apoptotic process
- protein K63-linked ubiquitination
- protein monoubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- organelle membrane
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding
- small GTPase binding