MAP3K15 Gene Summary [Human]
The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses. [provided by RefSeq, Jul 2010]
Details
| Type | Processed Transcript |
| Official Symbol | MAP3K15 |
| Official Name | mitogen-activated protein kinase kinase kinase 15 [Source:HGNC Symbol;Acc:HGNC:31689] |
| Ensembl ID | ENSG00000180815 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 15 |
| Synonyms | AABR07038029.1, ASK3, bA723P2.3, MEKK15, mitogen-activated protein kinase kinase kinase 15, RGD1560603 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP3K15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- HisK-N-like globin domain of the ASK signalosome
- Protein kinase domain
- MAP kinase kinase kinase
- kinase
- Serine/Threonine protein kinases, catalytic domain
- ASK kinase PH domain
- MAP3K TRAFs-binding domain
- Protein Kinases, catalytic domain
- Tetratricopeptide Repeats-Sensor
- Deoxyribohydrolase (DRHyd) domain of the ASK signalosome
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the MAP3K15 gene in human plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Cardiac Hypertrophy Signaling
- CD27 Signaling in Lymphocytes
- G-Protein Coupled Receptor Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- GNRH Signaling
- HGF Signaling
- Natural Killer Cell Signaling
- NGF Signaling
- PKCθ Signaling in T Lymphocytes
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- RANK Signaling in Osteoclasts
- Sertoli Cell-Sertoli Cell Junction Signaling
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP3K15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- cellular response to stress
Molecular Function
What the gene product does at the molecular level
- ATP binding
- metal ion binding
- MAP kinase kinase kinase activity