TNFRSF6B Gene Summary [Human]
This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Over-expression of this gene has been noted in gastrointestinal tract tumors. Read-through transcription into this gene from the neighboring upstream gene, which encodes regulator of telomere elongation helicase 1 (RTEL1), generates a non-coding transcript. [provided by RefSeq, Feb 2011]
Details
| Type | Protein Coding |
| Official Symbol | TNFRSF6B |
| Official Name | TNF receptor superfamily member 6b [Source:HGNC Symbol;Acc:HGNC:11921] |
| Ensembl ID | ENSG00000243509 |
| Bio databases IDs | |
| Aliases | TNF receptor superfamily member 6b |
| Synonyms | DCR3, DJ583P15.1.1, M68, M68E, TNF receptor superfamily member 6b, TR6 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNFRSF6B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- TNFR/NGFR cysteine-rich region
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- transmembrane receptor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- inflammatory bowel disease
- Crohn disease
- habitual abortion
- atopic dermatitis
- osteoarthritis
- experimental autoimmune encephalomyelitis
- ulcerative colitis
- graft-vs-host disease
- infection by Listeria monocytogenes
role in cell
- apoptosis
- differentiation
- expression in
- quantity
- growth
- cell death
- function
- activation
- proliferation
- cytotoxicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- Extracellular Space
- membrane surface
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNFRSF6B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity