ZFP91 Gene Summary [Human]
The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]
Details
| Type | Protein Coding |
| Official Symbol | ZFP91 |
| Official Name | ZFP91 zinc finger protein, atypical E3 ubiquitin ligase [Source:HGNC Symbol;Acc:HGNC:14983] |
| Ensembl ID | ENSG00000186660 |
| Bio databases IDs | |
| Aliases | ZFP91 zinc finger protein, atypical E3 ubiquitin ligase |
| Synonyms | 9130014I08Rik, A530054C17RIK, DMS-8, DSM-8, FKSG11, PZF, ZFP91 zinc finger protein, atypical E3 ubiquitin ligase, zinc finger protein 91, ZNF757 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZFP91 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- transcription regulator
- ubiquitin-protein transferase activity
- protein binding
- zinc finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- gastrointestinal neoplasia
- metabolic syndrome X
- lymphoma
- lymphomagenesis
- colorectal neoplasia
role in cell
- expression in
- activation in
- quantity
- glycolysis in
- infiltration by
- binding in
- replication in
- processing in
- autophagy in
- K63 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZFP91 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- activation of NF-kappaB-inducing kinase activity
- protein K63-linked ubiquitination
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- metal ion binding