PCDH10 Gene Summary [Human]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein is a cadherin-related neuronal receptor thought to function in the establishment of specific cell-cell connections in the brain. This gene plays a role in inhibiting cancer cell motility and cell migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

Details

Type
Protein Coding
Official Symbol
PCDH10
Official Name
protocadherin 10 [Source:HGNC Symbol;Acc:HGNC:13404]
Ensembl ID
ENSG00000138650
Bio databases IDs NCBI: 57575 Ensembl: ENSG00000138650
Aliases protocadherin 10
Synonyms 6430521D13RIK, 6430703F07Rik, mKIAA1400, OL-pc, OL-PCDH, PCDH19, protocadherin 10, RGD1565811
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PCDH10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Nap1-binding site
  • cytoplasmic domain
  • Cadherin-like
  • Cadherin repeat-like domain
  • Cadherin cytoplasmic C-terminal

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • cancer
  • metastasis
  • oral squamous cell carcinoma
  • squamous cell cancer of the oral cavity
  • advanced cancer
  • gait disturbance
  • hyperactive behavior
regulated by
role in cell
  • expression in
  • apoptosis
  • growth
  • colony formation by
  • elimination
  • elimination in
  • migration
  • development
  • adhesion
  • progression

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • glutaminergic synapse
  • cell surface
  • cellular membrane
  • actin filaments
  • cell-cell contacts
  • postsynaptic membrane
  • synaptic vesicles
  • synapse
  • extracellular matrix
  • perikaryon

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human PCDH10 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • nervous system development
  • cell adhesion
  • homophilic cell adhesion

Cellular Component

Where in the cell the gene product is active
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • calcium ion binding

Gene-Specific Assays for Results You Can Trust

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