GRK1 Gene Summary [Human]
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates rhodopsin and initiates its deactivation. Defects in GRK1 are known to cause Oguchi disease 2 (also known as stationary night blindness Oguchi type-2). [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GRK1 |
| Official Name | G protein-coupled receptor kinase 1 [Source:HGNC Symbol;Acc:HGNC:10013] |
| Ensembl ID | ENSG00000185974 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor kinase 1 |
| Synonyms | GPRK1, G protein-coupled receptor kinase 1, RHOK, RK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GRK1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Regulator of G protein signaling domain
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- rhodopsin kinase
- Regulator of G protein signaling (RGS) domain superfamily
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the GRK1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
- oguchi disease type 2
- retinal dystrophy
- alopecia areata
- Oguchi disease
- spinocerebellar ataxia type 7
- congenital stationary night blindness
role in cell
- apoptosis
- phosphorylation in
- abnormal morphology
- degeneration
- morphogenesis
- dark adaptation in
- electrophysiology
- inactivation in
- response
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- cytosol
- photoreceptor outer segments
- rod outer segments
- cone outer segments
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GRK1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein autophosphorylation
- rhodopsin mediated signaling pathway
- regulation of G-protein coupled receptor protein signaling pathway
- visual perception
- protein phosphorylation
- regulation of signal transduction
- regulation of rhodopsin mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- rhodopsin kinase activity
- protein kinase activity