PPP3R2 Gene Summary [Human]
Predicted to enable calcium ion binding activity and calcium-dependent protein serine/threonine phosphatase regulator activity. Predicted to be involved in regulation of catalytic activity. Predicted to act upstream of or within penetration of zona pellucida. Predicted to be located in sperm mitochondrial sheath. Predicted to be part of calcineurin complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PPP3R2 |
| Official Name | protein phosphatase 3 regulatory subunit B, beta [Source:HGNC Symbol;Acc:HGNC:9318] |
| Ensembl ID | ENSG00000188386 |
| Bio databases IDs | |
| Aliases | protein phosphatase 3 regulatory subunit B, beta, protein phosphatase 3, regulatory subunit B (calcineurin B)-like, calcineurin B, type II (19kDa), protein phosphatase 2B regulatory subunit 2 |
| Synonyms | Calcineurin B2, calcineurin B beta type 2, calcineurin B β type 2, CaNB2, Cblp, CnB2, CnB long, Pp2b B-Subunit Beta2, PP2B REGULATORY A subunit alpha3 (TESTIS-SPECIFIC), Pp2b Regulatory B Subunit Beta2 (Testes-Specific), PP2B REGULATORY subunit B alpha 3 (TESTES-SPECIFIC), PP2B REGULATORY subunit B α 3 (TESTES-SPECIFIC), PPP3RL, protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II), protein phosphatase 3 regulatory subunit B, beta, protein phosphatase 3, regulatory subunit B, beta, protein phosphatase 3, regulatory subunit B, α isoform (calcineurin B, type II), protein phosphatase 3 regulatory subunit B, β, protein phosphatase 3, regulatory subunit B, β |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP3R2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- autoinhibitory protein domain
- catalytic domain
- EF-hand domain pair
- EF hand
- EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family
- calmodulin binding domain
- EFh
- protein binding
- EFh_MICU
- calcium-dependent protein serine/threonine phosphatase regulator
- EFh_PI-PLC
Pathways
Biological processes and signaling networks where the PPP3R2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Autophagy
- B Cell Receptor Signaling
- Calcium Signaling
- Calcium-induced T Lymphocyte Apoptosis
- Clathrin-mediated Endocytosis Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- fMLP Signaling in Neutrophils
- Gap Junction Signaling
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- HIF1α Signaling
- IL-3 Signaling
- Netrin Signaling
- nNOS Signaling in Neurons
- Nur77 Signaling in T Lymphocytes
- Opioid Signaling Pathway
- PI3K Signaling in B Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Protein Kinase A Signaling
- RANK Signaling in Osteoclasts
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
- Role of NFAT in Cardiac Hypertrophy
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Synaptic Long Term Potentiation
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- leukemia
- toxic epidermal necrolysis
- interstitial fibrosis
- plasma cell myeloma
- diffuse large B-cell lymphoma
- breast cancer
- Sjögren syndrome
- refractory Hodgkin disease
- acute graft-vs-host disease
- chronic autoimmune hepatitis
role in cell
- penetration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- sperm midpiece
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP3R2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- penetration of zona pellucida
- protein dephosphorylation
- positive regulation of calcineurin-NFAT signaling cascade
Cellular Component
Where in the cell the gene product is active
- calcineurin complex
- protein serine/threonine phosphatase complex
- mitochondrion
- sperm mitochondrial sheath
- cytosol
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- protein binding
- calcium ion binding
- calcium-dependent protein serine/threonine phosphatase regulator activity