IL36A Gene Summary [Human]
The protein encoded by this gene is a cytokine that can activate NF-kappa-B and MAPK signaling pathways to generate an inflammatory response. The encoded protein functions primarily in skin and demonstrates increased expression in psoriasis. In addition, decreased expression of this gene has been linked to a poor prognosis in both hepatocellular carcinoma and colorectal cancer patients. [provided by RefSeq, Nov 2015]
Details
| Type | Protein Coding |
| Official Symbol | IL36A |
| Official Name | interleukin 36 alpha [Source:HGNC Symbol;Acc:HGNC:15562] |
| Ensembl ID | ENSG00000136694 |
| Bio databases IDs | |
| Aliases | interleukin 36 alpha |
| Synonyms | FIL1, FIL1E, FIL1(EPSILON), Fil1 ε, FIL1(ε), IL1(EPSILON), IL-1F6, IL1(ε), interleukin 36 alpha, interleukin 36, alpha, interleukin 36 α, interleukin 36, α |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IL36A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytokine
- beta-trefoil domain found in the interleukin-1 (IL-1) family of cytokines
Pathways
Biological processes and signaling networks where the IL36A gene in human plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Agranulocyte Adhesion and Diapedesis
- Atherosclerosis Signaling
- Cholecystokinin/Gastrin-mediated Signaling
- Communication between Innate and Adaptive Immune Cells
- Dendritic Cell Maturation
- Erythropoietin Signaling
- FXR/RXR Activation
- Graft-versus-Host Disease Signaling
- Granulocyte Adhesion and Diapedesis
- Hepatic Cholestasis
- HMGB1 Signaling
- IL-10 Signaling
- IL-6 Signaling
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- NF-κB Signaling
- p38 MAPK Signaling
- PPAR Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Systemic Lupus Erythematosus Signaling
- Toll-like Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pruritus
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- psoriatic lesion
- acute coronary syndrome
- psoriasis
role in cell
- expression in
- phosphorylation in
- proliferation
- production in
- activation in
- activation
- infiltration by
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IL36A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- cellular response to lipopolysaccharide
- inflammatory response to antigenic stimulus
- positive regulation of gene expression
- innate immune response
- cytokine-mediated signaling pathway
- positive regulation of interleukin-6 production
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- cytokine activity
- interleukin-1 receptor binding