FAM53B Gene Summary [Human]
Involved in positive regulation of canonical Wnt signaling pathway. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | FAM53B |
| Official Name | family with sequence similarity 53 member B [Source:HGNC Symbol;Acc:HGNC:28968] |
| Ensembl ID | ENSG00000189319 |
| Bio databases IDs | |
| Aliases | family with sequence similarity 53 member B, simplet homolog (zebrafish) |
| Synonyms | A930008G19Rik, bA12J10.2, family with sequence similarity 53 member B, family with sequence similarity 53, member B, KIAA0140, mKIAA0140, RGD1310799, smp |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FAM53B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Family of FAM53
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- alopecia
- male pattern hair loss
- cocaine dependence
- gout
- lung adenocarcinoma
- lung adenocarcinoma formation
- androgenic alopecia
role in cell
- assembly
- assembly in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FAM53B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of canonical Wnt receptor signaling pathway
- protein import into nucleus
- positive regulation of canonical Wnt receptor signaling pathway
- Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus