S100A14 Gene Summary [Human]
This gene encodes a member of the S100 protein family which contains an EF-hand motif and binds calcium. The gene is located in a cluster of S100 genes on chromosome 1. Levels of the encoded protein have been found to be lower in cancerous tissue and associated with metastasis suggesting a tumor suppressor function (PMID: 19956863, 19351828). [provided by RefSeq, Dec 2011]
Details
| Type | Protein Coding |
| Official Symbol | S100A14 |
| Official Name | S100 calcium binding protein A14 [Source:HGNC Symbol;Acc:HGNC:18901] |
| Ensembl ID | ENSG00000189334 |
| Bio databases IDs | |
| Aliases | S100 calcium binding protein A14 |
| Synonyms | 1110013O05Rik, BCMP84, LOC686203, S100A15, S100 calcium binding protein A14, S114 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human S100A14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- S-100/ICaBP type calcium binding domain
- chemokine receptor binding
- EFh
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- carcinoma in situ
- epithelial cancer in situ
- breast cancer
- pruritus
role in cell
- expression in
- proliferation
- apoptosis
- survival
- activation in
- cell death
- motility
- invasion
- chemotaxis
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- extracellular vesicles
- perinuclear region
- Plasma Membrane
- cytosol
- membrane ruffles
- actin stress fibers
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human S100A14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium ion homeostasis
- positive regulation of monocyte chemotaxis
- toll-like receptor 4 signaling pathway
- apoptotic process
- response to lipopolysaccharide
- defense response to bacterium
- positive regulation of granulocyte chemotaxis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- perinuclear region of cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- calcium-dependent protein binding
- chemokine receptor binding