Rps26 Gene Summary [Mouse]
A structural constituent of ribosome. Predicted to be involved in cytoplasmic translation and negative regulation of RNA splicing. Part of cytosolic small ribosomal subunit. Is active in synapse. Is expressed in palatal shelf and secondary palate. Human ortholog(s) of this gene implicated in Diamond-Blackfan anemia 10. Orthologous to several human genes including RPS26 (ribosomal protein S26). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Rps26 |
| Official Name | ribosomal protein S26 [Source:MGI Symbol;Acc:MGI:1351628] |
| Ensembl ID | ENSMUSG00000025362 |
| Bio databases IDs | |
| Aliases | ribosomal protein S26 |
| Synonyms | DBA10, eS26, Ribosomal Protein S26, S26 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rps26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- mRNA binding
- protein binding
- Ribosomal protein S26e
Pathways
Biological processes and signaling networks where the Rps26 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diamond-blackfan anemia type 10
- metabolic syndrome X
- Diamond-Blackfan anemia
- psoriasis
- dermatological disorder
- Diamond-Blackfan anemia type 15 with mandibulofacial dysostosis
- asthma
- insulin-dependent diabetes mellitus
- actinic keratosis
regulates
- RNR
role in cell
- nuclear export in
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- cytosol
- nucleoplasm
- synapse
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rps26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translation
- negative regulation of RNA splicing
- translation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- cytosolic small ribosomal subunit
- membrane
- cytosol
- small ribosomal subunit
- synapse
- ribosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- structural constituent of ribosome
- cadherin binding
- mRNA binding