MAP1LC3C Gene Summary [Human]
Autophagy is a highly regulated bulk degradation process that plays an important role in cellular maintenance and development. MAP1LC3C is an ortholog of the yeast autophagosome protein Atg8 (He et al., 2003 [PubMed 12740394]).[supplied by OMIM, Nov 2010]
Details
| Type | Protein Coding |
| Official Symbol | MAP1LC3C |
| Official Name | microtubule associated protein 1 light chain 3 gamma [Source:HGNC Symbol;Acc:HGNC:13353] |
| Ensembl ID | ENSG00000197769 |
| Bio databases IDs | |
| Aliases | microtubule associated protein 1 light chain 3 gamma |
| Synonyms | ATG8J, LC3C, microtubule associated protein 1 light chain 3 gamma, microtubule associated protein 1 light chain 3 γ |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP1LC3C often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Ubl1_cv_Nsp3_N-like
- phosphatidylethanolamine binding
- protein binding
Pathways
Biological processes and signaling networks where the MAP1LC3C gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lymphomagenesis
- diabetic nephropathy
- primary central nervous system lymphoma
- primary cancer
- central nervous system cancer
role in cell
- accumulation in
- replication in
- fusion
- size
- fusion in
- macroautophagy in
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoplasmic ribonucleoprotein granule
- cellular membrane
- cytosol
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP1LC3C gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagic vacuole assembly
- protein exit from endoplasmic reticulum
- cellular response to starvation
- aggrephagy
- mitochondrion degradation
- macroautophagy
- cellular response to nitrogen starvation
Cellular Component
Where in the cell the gene product is active
- endomembrane system
- cytoplasmic vesicle
- cytosol
- organelle membrane
- autophagic vacuole membrane
- autophagic vacuole
- microtubule
Molecular Function
What the gene product does at the molecular level
- phosphatidylethanolamine binding
- ubiquitin protein ligase binding
- protein binding