DLL1 Gene Summary [Human]
DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DLL1 |
| Official Name | delta like canonical Notch ligand 1 [Source:HGNC Symbol;Acc:HGNC:2908] |
| Ensembl ID | ENSG00000198719 |
| Bio databases IDs | |
| Aliases | delta like canonical Notch ligand 1 |
| Synonyms | Delta, DELTA1, delta like canonical Notch ligand 1, DL-1, NEDBAS, δ, δ like 1, δ like canonical Notch ligand 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DLL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- N terminus of Notch ligand C2-like domain
- ectodomain
- Human growth factor-like EGF
- transcription factor binding
- enzyme
- protein binding
- EGF_CA
- Delta serrate ligand
- ATEV motif
- Lin-12/Notch repeat
- cytoplasmic domain
- intracellular domain
- receptor agonist activity
- PDZ binding motif
- EGF repeat
- notch binding
Pathways
Biological processes and signaling networks where the DLL1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Alzheimer disease
- organismal death
- neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures
- experimental autoimmune encephalomyelitis
- metastasis
- acute myeloid leukemia
- hereditary disorder
- hypoxia
- rib fusion
role in cell
- expression in
- activation in
- proliferation
- activation
- growth
- generation
- differentiation
- migration
- apoptosis
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- cell borders
- cellular membrane
- cell-cell contacts
- apical membrane
- neurites
- cytoplasmic vesicles
- membrane rafts
- cellular protrusions
- perikaryon
- axon terminals
- cell-cell adherens junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DLL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of auditory receptor cell differentiation
- neuroepithelial cell differentiation
- negative regulation of epidermal cell differentiation
- negative regulation of interleukin-10 production
- retina development in camera-type eye
- positive regulation of endocytosis
- retina morphogenesis in camera-type eye
- negative regulation of glial cell apoptotic process
- inhibition of neuroepithelial cell differentiation
- positive regulation of skeletal muscle tissue growth
- proximal/distal pattern formation
- spinal cord development
- loop of Henle development
- clathrin-mediated endocytosis
- marginal zone B cell differentiation
- regulation of vascular endothelial growth factor receptor signaling pathway
- energy homeostasis
- heart looping
- cell fate determination
- negative regulation of hemocyte differentiation
- compartment pattern specification
- regulation of growth
- regulation of vascular endothelial growth factor signaling pathway
- negative regulation of epithelial cell differentiation
- Notch signaling pathway
- proximal tubule development
- somitogenesis
- negative regulation of myoblast differentiation
- somite specification
- positive regulation of gene expression
- negative regulation of cardiac muscle cell differentiation
- myeloid cell differentiation
- regulation of neurogenesis
- organ growth
- astrocyte development
- hemopoiesis
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- negative regulation of neuron differentiation
- negative regulation of Notch signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- neuronal stem cell maintenance
- positive regulation of Notch signaling pathway
- regulation of cell division
- endothelial tip cell fate specification
- neuron fate specification
- negative regulation of cell differentiation
- nephron development
- left/right axis specification
- negative regulation of myeloid cell differentiation
- cerebellar molecular layer formation
- regulation of blood pressure
- Notch signaling pathway involved in arterial endothelial cell fate commitment
- determination of left/right symmetry
- type B pancreatic cell development
- cerebellar Purkinje cell layer structural organization
- auditory receptor cell differentiation
- regulation of skeletal muscle tissue growth
- regulation of somitogenesis
- skeletal muscle tissue growth
- lateral inhibition
- cell differentiation
- regulation of cell adhesion
Cellular Component
Where in the cell the gene product is active
- adherens junction
- membrane raft
- cytoplasmic vesicle
- extracellular region
- plasma membrane
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- scaffold protein binding
- protein binding
- Tat protein binding
- calcium ion binding
- Notch binding
- receptor agonist activity