PFDN6 Gene Summary [Human]
PFDN6 is a subunit of the heteromeric prefoldin complex that chaperones nascent actin (see MIM 102560) and alpha- and beta-tubulin (see MIM 602529 and MIM 191130, respectively) chains pending their transfer to the cytosolic chaperonin containing TCP1 (MIM 186980) (CCT) complex (Hansen et al., 1999 [PubMed 10209023]).[supplied by OMIM, Jul 2010]
Details
| Type | Protein Coding |
| Official Symbol | PFDN6 |
| Official Name | prefoldin subunit 6 [Source:HGNC Symbol;Acc:HGNC:4926] |
| Ensembl ID | ENSG00000204220 |
| Bio databases IDs | |
| Aliases | prefoldin subunit 6 |
| Synonyms | H2-KE2, HKE2, KE-2, Major histocompatibility complex class ii, PFD6, prefoldin subunit 6 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PFDN6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- prefoldin, beta subunit, archaeal
- Prefoldin subunit
- prefoldin
- protein binding
- chaperone binding
- beta-amyloid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PFDN6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chaperone-mediated protein folding
- chaperone-mediated protein complex assembly
- protein folding
- protein stabilization
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- prefoldin complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- chaperone binding
- unfolded protein binding
- beta-amyloid binding