PPP1R11 Gene Summary [Human]
This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PPP1R11 |
| Official Name | protein phosphatase 1 regulatory inhibitor subunit 11 [Source:HGNC Symbol;Acc:HGNC:9285] |
| Ensembl ID | ENSG00000204619 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1 regulatory inhibitor subunit 11 |
| Synonyms | 1500041B02Rik, AV117883, CFAP255, HCG-V, INH-3, IPP3, protein phosphatase 1 regulatory inhibitor subunit 11, protein phosphatase 1, regulatory (inhibitor) subunit 11, protein phosphatase 1, regulatory inhibitor subunit 11, TCTE5, TCTEX5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PPP1R11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Protein phosphatase inhibitor
- protein phosphatase inhibitor activity
- ubiquitin protein ligase activity
- enzyme
- protein binding
- phosphatase binding
Pathways
Biological processes and signaling networks where the PPP1R11 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PPP1R11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cytokine production
- defense response to Gram-positive bacterium
- ubiquitin-dependent protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- protein serine/threonine phosphatase inhibitor activity
- protein phosphatase inhibitor activity
- protein binding
- protein phosphatase 1 binding