TRIM13 Gene Summary [Human]
This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene is located on chromosome 13 within the minimal deletion region for B-cell chronic lymphocytic leukemia. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TRIM13 |
| Official Name | tripartite motif containing 13 [Source:HGNC Symbol;Acc:HGNC:9976] |
| Ensembl ID | ENSG00000204977 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 13 |
| Synonyms | 3110001L12Rik, CAR, DLEU5, LEU5, RET FINGER protein 2, RFP2, RNF77, tripartite motif-containing 13 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription co-activator
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- coiled-coil domain
- enzyme
- Ring finger domain
- protein binding
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- transmembrane domain
- B-box zinc finger
- ubiquitin-like-protein ligase
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- coronary stenosis
- atherosclerosis
regulated by
- IL1B
- HeLa cells
- mifepristone
role in cell
- expression in
- phosphorylation in
- apoptosis
- formation
- degradation in
- innate immune response in
- ubiquitination in
- macroautophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- membrane fraction
- Endoplasmic Reticulum
- granules
- reticular perinuclear compartment
- endoplasmic reticulum membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of macroautophagy
- proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of transcription, DNA-dependent
- innate immune response
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- anatomical structure morphogenesis
- positive regulation of NF-kappaB transcription factor activity
- negative regulation of viral transcription
- protein ubiquitination
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear endoplasmic reticulum
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding
- transcription coactivator activity