Scmh1 Gene Summary [Mouse]
Predicted to enable chromatin binding activity and histone binding activity. Acts upstream of or within anterior/posterior pattern specification; chromatin remodeling; and spermatogenesis. Located in chromocenter and male germ cell nucleus. Is expressed in several structures, including branchial arch; genitourinary system; gut; limb; and nervous system. Orthologous to human SCMH1 (Scm polycomb group protein homolog 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scmh1 |
| Official Name | sex comb on midleg homolog 1 [Source:MGI Symbol;Acc:MGI:1352762] |
| Ensembl ID | ENSMUSG00000000085 |
| Bio databases IDs | |
| Aliases | sex comb on midleg homolog 1 |
| Synonyms | Scml1, Scml3, Scm polycomb group homolog 1, Scm polycomb group protein homolog 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Scmh1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPM domain
- SLED domain
- Sterile alpha motif
- transcription regulator
- Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
- mbt repeat
- SAM (Sterile alpha motif )
- RNA binding Region
- SAM domain (Sterile alpha motif)
- protein binding
- malignant brain tumor (MBT) repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- azoospermia
- atrial fibrillation
- colorectal cancer
- cardioembolic stroke
- myeloid hyperplasia
role in cell
- number
- abnormal morphology
- remodeling
- replicative senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- chromosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Scmh1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- heterochromatin assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding
- chromatin binding