Sfmbt2 Gene Summary [Mouse]
Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription and negative regulation of gene expression. Predicted to be located in aggresome; cytosol; and nuclear speck. Predicted to be active in nucleus. Is expressed in several structures, including extraembryonic component; liver; lung; placenta; and spleen. Orthologous to human SFMBT2 (Scm like with four mbt domains 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sfmbt2 |
| Official Name | Scm-like with four mbt domains 2 [Source:MGI Symbol;Acc:MGI:2447794] |
| Ensembl ID | ENSMUSG00000061186 |
| Bio databases IDs | |
| Aliases | Scm-like with four mbt domains 2 |
| Synonyms | D2Wsu23e, D330030P06Rik, Scm-like with four mbt domains 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sfmbt2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SLED domain
- Sterile alpha motif
- histone binding
- Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
- mbt repeat
- SAM (Sterile alpha motif )
- SAM domain (Sterile alpha motif)
- protein binding
- malignant brain tumor (MBT) repeat
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- organismal death
- Huntington disease
- abdominal cancer
- myasthenia gravis
- tinnitus
- habitual abortion
- nephrosis
- uterine cancer
- female genital tract cancer
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- aggresome
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
- nuclear bodies
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sfmbt2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression
- negative regulation of transcription, DNA-dependent
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- nuclear speck
- intracellular membrane-bounded organelle
- cytosol
- aggresome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding
- transcription corepressor activity
- chromatin binding