Tpd52l1 Gene Summary [Mouse]
Predicted to enable protein homodimerization activity. Predicted to be involved in G2/M transition of mitotic cell cycle and positive regulation of signal transduction. Predicted to be located in early endosome and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in brain; limb bud; otic capsule; and temporal bone petrous part. Orthologous to human TPD52L1 (TPD52 like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tpd52l1 |
| Official Name | tumor protein D52-like 1 [Source:MGI Symbol;Acc:MGI:1298386] |
| Ensembl ID | ENSMUSG00000000296 |
| Bio databases IDs | |
| Aliases | tumor protein D52-like 1 |
| Synonyms | D53, HD53, LOC681676, TPD52L, TPD52 like 1, TPD53, tumor protein D52-like 1, tumour protein D52-like 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tpd52l1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Tumour protein D52 family
- protein homodimerization
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- colon cancer
- colorectal adenoma
- colorectal adenoma formation
- endometriosis
role in cell
- migration
- apoptosis
- proliferation
- G2/M phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular nanovesicle
- pH resistant lipid raft fraction
- perinuclear region
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tpd52l1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- G2/M transition of mitotic cell cycle
- positive regulation of JNK cascade
- positive regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- perinuclear region of cytoplasm
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- protein binding