Icosl Gene Summary [Mouse]
Predicted to enable identical protein binding activity and signaling receptor binding activity. Involved in positive regulation of interleukin-4 production. Located in external side of plasma membrane. Is expressed in several structures, including extraembryonic component; gonad; hemolymphoid system gland; liver; and stomach. Orthologous to human ICOSLG (inducible T cell costimulator ligand). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Icosl |
| Official Name | icos ligand [Source:MGI Symbol;Acc:MGI:1354701] |
| Ensembl ID | ENSMUSG00000000732 |
| Bio databases IDs | |
| Aliases | icos ligand |
| Synonyms | B7h, B7-H2, B7 homolog 2, B7-related protein-1, B7RP-1, CD275, GI50, GL50, ICOS-L, ICOS LIGAND, IMD119, inducible T-cell co-stimulator ligand, LICOS, Ly115l, mKIAA0653, RGD1562791 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Icosl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- immunoglobin constant region like domain
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- receptor agonist activity
- protein binding
- receptor binding
- Ig-like V domain
- identical protein binding
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Icosl gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- arthritis
- rheumatoid arthritis
- chronic eosinophilic rhinosinusitis
- pediatric inflammatory bowel disease
- hyperplasia
- metastasis
- combined immunodeficiency
- hereditary disorder
- plasmacytosis
role in cell
- apoptosis
- production in
- expression in
- migration
- activation in
- proliferation
- survival
- quantity
- accumulation
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- Extracellular Space
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Icosl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- T cell activation
- adaptive immune response
- B cell activation
- regulation of cytokine production
- defense response
- positive regulation of activated T cell proliferation
- hyperosmotic response
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- membrane
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- receptor binding