Nhp2 Gene Summary [Mouse]
Predicted to enable RNA binding activity. Predicted to be involved in snRNA pseudouridine synthesis; snoRNA guided rRNA pseudouridine synthesis; and telomere maintenance via telomerase. Predicted to be located in Cajal body. Predicted to be part of box H/ACA snoRNP complex and box H/ACA telomerase RNP complex. Is expressed in axial musculature; orbito-sphenoid; and pancreas mesenchyme. Human ortholog(s) of this gene implicated in autosomal recessive dyskeratosis congenita 2. Orthologous to human NHP2 (NHP2 ribonucleoprotein). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nhp2 |
| Official Name | NHP2 ribonucleoprotein [Source:MGI Symbol;Acc:MGI:1098547] |
| Ensembl ID | ENSMUSG00000001056 |
| Bio databases IDs | |
| Aliases | NHP2 ribonucleoprotein |
| Synonyms | 2410130M07Rik, D11Ertd175e, DKCB2, LOC100910210, LOC103690013, NHP2P, NHP2 ribonucleoprotein, NOLA2, Nola2 (predicted) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Nhp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
- mRNA 3' UTR binding
- U4/U6.U5 small nuclear ribonucleoprotein SNU13
- snoRNA binding
- protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- dense fibrillar component
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- Cajal bodies
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Nhp2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rRNA pseudouridine synthesis
- snRNA pseudouridine synthesis
- telomere maintenance via telomerase
Cellular Component
Where in the cell the gene product is active
- box H/ACA snoRNP complex
- chromosome, telomeric region
- box H/ACA scaRNP complex
- telomerase holoenzyme complex
- small nucleolar ribonucleoprotein complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- telomeric RNA binding
- box H/ACA snoRNA binding