Gda Gene Summary [Mouse]
Enables guanine deaminase activity. Involved in allantoin metabolic process; amide catabolic process; and nucleobase-containing small molecule metabolic process. Is active in cytosol. Is expressed in several structures, including adrenal gland; brain; and peripheral nervous system ganglion. Orthologous to human GDA (guanine deaminase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gda |
| Official Name | guanine deaminase [Source:MGI Symbol;Acc:MGI:95678] |
| Ensembl ID | ENSMUSG00000058624 |
| Bio databases IDs | |
| Aliases | guanine deaminase |
| Synonyms | CYPIN, GAH, GUANASE, Guanine aminohydrolase, Guanine deaminase, LOC101927127, NEDASIN |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gda often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- zinc ion binding
- Amidohydrolase family
- enzyme
- guanine deaminase
- protein binding
- metallo-dependent_hydrolases
- CRMP homology domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- ischemic stroke
- scarlet fever
- hepatocellular carcinoma
role in cell
- cell death
- quantity
- size
- density
- replicative senescence
- assembly
- polymerization
- regulation
- patterning
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic region
- cytosol
- synaptic vesicles
- synaptosomes
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gda gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- guanine metabolic process
- cellular amide catabolic process
- deoxyguanosine catabolic process
- dGMP catabolic process
- nervous system development
- GMP catabolic process
- nucleobase-containing compound metabolic process
- guanine catabolic process
- allantoin metabolic process
Cellular Component
Where in the cell the gene product is active
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- guanine deaminase activity