Akap8l Gene Summary [Mouse]
Predicted to enable histone deacetylase binding activity; lamin binding activity; and protein kinase A regulatory subunit binding activity. Predicted to be involved in several processes, including cell cycle G2/M phase transition; mitotic chromosome condensation; and regulation of mRNA export from nucleus. Located in nuclear matrix. Is expressed in several structures, including central nervous system and retina. Orthologous to human AKAP8L (A-kinase anchoring protein 8 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Akap8l |
| Official Name | A kinase (PRKA) anchor protein 8-like [Source:MGI Symbol;Acc:MGI:1860606] |
| Ensembl ID | ENSMUSG00000002625 |
| Bio databases IDs | |
| Aliases | A kinase (PRKA) anchor protein 8-like |
| Synonyms | A-kinase anchoring protein 8 like, A kinase anchor protein 8-like, HA95, HAP95, NAKAP, NAKAP95, NEIGHBOR of A-KINASE ANCHORING protein 95 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Akap8l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DEAD/H-box RNA helicase binding
- A-kinase anchoring protein 95 (AKAP95)
- lamin binding
- histone deacetylase binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- uterine leiomyoma
- leiomyomatosis
- organismal death
role in cell
- proliferation
- translation in
- condensation
- survival
- number
- size
- oxaliplatin resistance
- sphere formation by
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
- nuclear speckles
- nuclear matrix
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Akap8l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- mitotic chromosome condensation
- mRNA processing
- positive regulation of transcription from RNA polymerase II promoter
- nuclear envelope disassembly
- regulation of mRNA export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- PML body
- cytoplasm
- nuclear speck
- nuclear matrix
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- RNA binding
- histone deacetylase binding
- metal ion binding
- DEAD/H-box RNA helicase binding
- protein kinase A regulatory subunit binding
- lamin binding