Zdhhc21 Gene Summary [Mouse]
Enables protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including peptidyl-L-cysteine S-palmitoylation; regulation of establishment of endothelial barrier; and regulation of vascular associated smooth muscle contraction. Acts upstream of or within hair follicle development; protein palmitoylation; and sebaceous gland development. Predicted to be located in plasma membrane. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Is expressed in early conceptus; eye; inner cell mass; oocyte; and trunk somite. Orthologous to human ZDHHC21 (zinc finger DHHC-type palmitoyltransferase 21). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zdhhc21 |
| Official Name | zinc finger, DHHC domain containing 21 [Source:MGI Symbol;Acc:MGI:1915518] |
| Ensembl ID | ENSMUSG00000028403 |
| Bio databases IDs | |
| Aliases | zinc finger, DHHC domain containing 21 |
| Synonyms | 9130404H11Rik, D130004H04RIK, dep, DHHC-21, DNZ1, HSPC097, zinc finger, DHHC domain containing 21, zinc finger DHHC-type palmitoyltransferase 21 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zdhhc21 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyltransferase
- protein-cysteine S-palmitoleyltransferase
- DHHC palmitoyltransferase
- enzyme
- protein binding
Pathways
Biological processes and signaling networks where the Zdhhc21 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- major depression
- leukemogenesis
- lung adenocarcinoma
- lung adenocarcinoma formation
regulated by
- MYB family
- LHX1
- budesonide
role in cell
- phosphorylation in
- activation in
- differentiation
- proliferation
- oxidative phosphorylation in
- palmitoylation in
- release in
- G0/G1 phase transition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Golgi region
- cellular membrane
- Golgi Apparatus
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zdhhc21 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- hair follicle development
- peptidyl-L-cysteine S-palmitoylation
- adrenergic receptor signaling pathway
- protein palmitoylation
- sebaceous gland development
- regulation of vascular smooth muscle contraction
- protein targeting to membrane
- nitric oxide metabolic process
Cellular Component
Where in the cell the gene product is active
- Golgi membrane
- Golgi apparatus
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein-cysteine S-palmitoleyltransferase activity
- protein binding
- palmitoyltransferase activity