Kcnn1 Gene Summary [Mouse]

Enables calmodulin binding activity. Predicted to be involved in potassium ion transmembrane transport. Located in cytoplasm and plasma membrane. Is expressed in brain; heart; peripheral nervous system; and testis. Orthologous to human KCNN1 (potassium calcium-activated channel subfamily N member 1). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Kcnn1
Official Name
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1 [Source:MGI Symbol;Acc:MGI:1933993]
Ensembl ID
ENSMUSG00000002908
Bio databases IDs NCBI: 84036 Ensembl: ENSMUSG00000002908
Aliases potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1
Synonyms AC019302.1, Gm3624, hSK1, KCa2.1, LOC100360811, potassium calcium-activated channel subfamily N member 1, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 1, SK1, SKCA1
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kcnn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Calcium-activated SK potassium channel
  • inward rectifier potassium channel
  • binding protein
  • calmodulin binding
  • small conductance calcium-activated potassium channel
  • calmodulin binding domain
  • calcium-activated potassium channel
  • alpha helix
  • ion channel
  • HR1

Pathways

Biological processes and signaling networks where the Kcnn1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • acute myeloid leukemia
  • opioid-related disorder
regulated by
regulates
  • K+

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • Cytoplasm
  • cellular membrane
  • synaptic vesicles
  • perikaryon
  • mossy fibers

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Kcnn1 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • potassium ion transport
  • potassium ion transmembrane transport
  • synaptic transmission

Cellular Component

Where in the cell the gene product is active
  • voltage-gated potassium channel complex
  • synapse
  • neuronal cell body
  • neuron projection
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • calcium-activated potassium channel activity
  • calmodulin binding
  • inward rectifier potassium channel activity
  • small conductance calcium-activated potassium channel activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.