Med24 Gene Summary [Mouse]

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene may form a submodule of the mediator complex that magnifies the effects of activators on the general transcription machinery. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]

Details

Type
Retained Intron
Official Symbol
Med24
Official Name
mediator complex subunit 24 [Source:MGI Symbol;Acc:MGI:1344385]
Ensembl ID
ENSMUSG00000017210
Bio databases IDs NCBI: 23989 Ensembl: ENSMUSG00000017210
Aliases mediator complex subunit 24
Synonyms 911GSE, ARC100, CRSP100, CRSP4, D11Ertd307e, DRIP100, GSE2, Med100, MED5, mediator complex subunit 24, Pparb2, Pparbp2, THRAP4, TRAP100
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Med24 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • transcription regulator
  • histone acetyltransferase
  • transcription co-activator
  • binding protein
  • ubiquitin protein ligase activity
  • transcription cofactor
  • Mediator complex subunit 24 N-terminal
  • protein binding
  • thyroid hormone receptor binding

Pathways

Biological processes and signaling networks where the Med24 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • major depression
  • plasma cell myeloma
  • neuroticism
  • asthma
  • cardiovascular disorder
  • pancreatic carcinoma
  • pancreatic epithelial cancer
  • neurotic disorder
  • neutropenia
  • leukopenia
regulated by
  • beta-estradiol
  • GnRH analog
  • EPAS1
  • MED1
  • testosterone
  • metribolone
  • PLN
  • BCL6
  • L-triiodothyronine
  • QKI
regulates
  • PPARG
  • DNA endogenous promoter
  • RNA polymerase II
  • reporter gene
  • RELA
  • TBP
  • HAMP
  • DNA promoter
  • Trap/Mediator
  • CDK8
role in cell
  • survival
  • cell viability
  • olaparib resistance

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • interchromatin granule cluster fractions
  • nuclear fraction
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Med24 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • positive regulation of transcription elongation from RNA polymerase II promoter
  • RNA polymerase II transcriptional preinitiation complex assembly
  • positive regulation of transcription initiation from RNA polymerase II promoter
  • positive regulation of transcription, DNA-dependent

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • core mediator complex
  • mediator complex
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • transcription cofactor activity
  • transcription coactivator activity
  • ligand-dependent nuclear receptor transcription coactivator activity
  • vitamin D receptor binding
  • thyroid hormone receptor binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.