Calb2 Gene Summary [Mouse]
Enables calcium ion binding activity involved in regulation of presynaptic cytosolic calcium ion concentration. Predicted to be involved in regulation of presynaptic cytosolic calcium ion concentration. Located in dendriole and gap junction. Is active in parallel fiber to Purkinje cell synapse. Is expressed in several structures, including alimentary system; nervous system; reproductive system; respiratory system; and sensory organ. Orthologous to human CALB2 (calbindin 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Calb2 |
| Official Name | calbindin 2 [Source:MGI Symbol;Acc:MGI:101914] |
| Ensembl ID | ENSMUSG00000003657 |
| Bio databases IDs | |
| Aliases | calbindin 2 |
| Synonyms | CAB29, CAL2, calbindin 2, CALRETININ, CR |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Calb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-hand, calcium binding motif
- EF-hand domain
- EF-hand, calcium binding motif, found in the hexa-EF hand proteins family
- EF-hand domain pair
- EF hand
- calcium ion binding
- EFh
- EF-hand, calcium binding motif, found in CREC-EF hand family
Pathways
Biological processes and signaling networks where the Calb2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- epithelial neoplasia
- adrenal cortex neoplasm
- schizophrenia
- mesothelioma
- mesothelioma formation
- sex cord stromal neoplasm
- medulloblastoma
- brain cancer
role in cell
- proliferation
- survival
- inactivation in
- facilitation in
- long-term potentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- stereocilia
- neurites
- nerve ending
- synapse
- cuticular plate
- stereocilia bundles
- gap junctions
- perikaryon
- axons
- dendrites
- axon terminals
- postsynaptic terminals
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Calb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of long-term synaptic potentiation
Cellular Component
Where in the cell the gene product is active
- gap junction
- nucleus
- dendrite
- terminal button
- cytosol
- synapse
Molecular Function
What the gene product does at the molecular level
- calcium ion binding