Col5a3 Gene Summary [Mouse]
Enables heparin binding activity. Acts upstream of or within cell-matrix adhesion. Part of collagen type V trimer. Is expressed in several structures, including bone; embryo mesenchyme; extraembryonic component; placenta; and tongue. Orthologous to human COL5A3 (collagen type V alpha 3 chain). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Col5a3 |
| Official Name | collagen, type V, alpha 3 [Source:MGI Symbol;Acc:MGI:1858212] |
| Ensembl ID | ENSMUSG00000004098 |
| Bio databases IDs | |
| Aliases | collagen, type V, alpha 3 |
| Synonyms | Alpha4(v) collagen, collagen, type V, alpha 3, collagen type V alpha 3 chain, collagen, type V, α 3, collagen type V α 3 chain |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Col5a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fibrillar collagen C-terminal domain
- binding protein
- LamG
- heparin binding domain
- Collagen triple helix repeat (20 copies)
- protein binding
- structural molecule
- basic domain
- heparin binding
Pathways
Biological processes and signaling networks where the Col5a3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Dupuytren contracture
- colorectal cancer
- diabetic foot ulcer disorder
- burn
- cellulite of the buttocks
- hyperglycemia
- obesity
- Peyronie disease
- insulin resistance
- weight loss
role in cell
- apoptosis
- number
- adhesion
- cell spreading
- organization
- assembly
- mass
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- endoplasmic reticulum lumen
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Col5a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- extracellular matrix organization
- collagen fibril organization
- skin development
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular region
- collagen type V
Molecular Function
What the gene product does at the molecular level
- collagen binding
- proteoglycan binding
- extracellular matrix structural constituent conferring tensile strength
- heparin binding
- extracellular matrix structural constituent