Ppan Gene Summary [Mouse]
Predicted to enable rRNA binding activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to act upstream of or within regulation of cell growth by extracellular stimulus. Predicted to be located in nucleus. Predicted to be part of preribosome, large subunit precursor. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to several human genes including PPAN (peter pan homolog). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppan |
| Official Name | peter pan homolog [Source:MGI Symbol;Acc:MGI:2178445] |
| Ensembl ID | ENSMUSG00000004100 |
| Bio databases IDs | |
| Aliases | peter pan homolog |
| Synonyms | A230087P06Rik, BXDC3, LOC100360094, peter pan homolog, SSF, SSF-1, SSF2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppan often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Brix domain
- The Brix domain is found in a number of eukaryotic proteins
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- narcolepsy with cataplexy
role in cell
- depolarization
- growth by
- replication in
- degradation in
- depolarization in
- processing in
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Mitochondria
- cytosol
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppan gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rRNA processing
- ribosomal large subunit assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleolus
- preribosome, large subunit precursor
Molecular Function
What the gene product does at the molecular level
- RNA binding
- rRNA binding